简  介

蒋焱熠，男，中科院合肥物质科学研究院健康与医学技术研究所研究员，博士生导师。2014年于中国医学科学院/北京协和医学院/清华大学获理学博士学位，2014年至2020年先后在新加坡国立大学（NUS）和加州大学洛杉矶分校（UCLA）医学院Cedars-Sinai医学中心从事博士后研究，2020年12月加入中科院合肥物质科学研究院健康与医学技术研究所，建立癌变机理与精准治疗课题组。

研究方向

1、肿瘤微环境与肿瘤免疫逃逸。

2、肿瘤微环境中功能性免疫细胞的表观遗传修饰。

发表论文

在国内外重要学术刊物发表论文40余篇，其中SCI学术论文36篇，刊登在Nature Genetics、Gastroenterology、Gut和Nature Communications等刊物。

部分代表作：

1. Jiang YY^#, Jiang Y^#*, Li CQ^#, Zhang Y^#, Dakle P^#, Kaur H, Deng JW, Lin RYT, Han L, Xie JJ, Yan YW, Doan N, Zheng YY, Mayakonda A, Hazawa M, Xu L, Li YY, Aswad L, Jeitany M, Kanojia D, Guan XY, Said JW, Yang W, Fullwood MJ^*, Lin DC^*, Koeffler HP. TP63, SOX2 and KLF5 Establish Core Regulatory Circuitry and Construct Cancer Specific Epigenome in Esophageal Squamous Cell Carcinoma Cell lines. Gastroenterology. 2020 Oct;159(4):1311-1327.e19.

2. Jiang YY^#*, Lin DC^#*, Mayakonda A^#, Hazawa M, Ding LW, Chien WW, Xu L, Chen Y, Xiao JF, Senapedis W, Baloglu E, Kanojia E, Shang L, Xu X, Yang H, Tyner JW, Wang MR^*, Koeffler HP. Targeting Super-Enhancer associated oncogenes in esophageal squamous cell carcinoma. Gut. 2017 Aug; 66 (8): 1358-1368.

3. Jiang YY, Shang L, Shi ZZ, Zhang TT, Ma S, Zhang Y, Hao JJ, Shi C, Shi F, Xu X, Cai Y, Zhan QM, Wang MR^*. Microtubule-associated protein 4 (MAP4) is an important regulator of cell invasion/migration and a potential therapeutic target in esophageal squamous cell carcinoma. Oncogene. 2016 Sep15; 35 (37): 4846-56.

4. Jiang Y^#, Jiang YY^#*, Xie JJ^#, Mayakonda A^#, Chen L, Xiao JF, Li CQ, Huang ML, Ding LW, Sun QY, Xu L, Kanojia D, Jeitany M, Deng JW, Liao LD, Soukiasian HJ, Berman BP, Hao JJ, Xu LY, Li EM, Wang MR, Bi XG, Lin DC^*, Koeffler HP. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression. Nat Commun. 2018 Sep 6; 9 (1): 3619.

5. Jiang Y^#, Jiang YY^#*, Mayakonda A, Huang ML, Ding LW, Lin H, Yu FG, Lu YN, Loh TS, Chow M, Savage S, Tyner JW, Lin DC^*, Koeffler HP. Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma. Cancer Res. 2017 Dec 1; 77 (23): 6614-6626.

6. Hao JJ^#, Lin DC^#*, Dinh HQ^#, Mayakonda A^#, Jiang YY^#, Chang C, Jiang Y, Lu CC, Shi ZZ, Xu X, Zhang Y, Cai Y, Wang JW, Zhan QM, Wei WQ^*, Berman BP^*, Wang MR^*, Koeffler HP. Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma. Nat Genet. 2016 Dec; 48 (12): 1500-1507.

7. Chen L^#, Huang M^#*, Plummer J^#, Pan J^#, Jiang YY^#, Yang Q, Silva TC, Gull N, Chen S, Ding LW, An O, Yang H, Cheng Y, Said JW, Doan N, Dinjens WN, Waters KM, Tuli R, Gayther SA, Klempner SJ, Berman BP, Meltzer SJ, Lin DC^*, Koeffler HP. Master transcription factors form inter-connected circuitry and orchestrate transcriptional network in esophageal adenocarcinoma. Gut. 2020 Apr; 69 (4): 630-640.

8. Lin LH^#, Huang ML^#*, Shi XP^#, Mayakonda A, Hu KS, Jiang YY, Guo X, Chen L, Pang B, Doan N, Said, JW, Xie JJ, Gery S, Cheng X, Lin ZY, Li JS, Benjamin BP, Yin D^*, Lin DC^*, Koeffler HP. Super-enhancer-associated MEIS1 Promotes Transcriptional Dysregulation in Ewing Sarcoma in Co-Operation With EWS-FLI1. Nucleic Acids Res. 2019 Feb 20; 47 (3):1255-1267.

9. Lin DC^#*, Dinh HQ^#, Xie JJ^#*, Mayakonda A^#, Silva TC, Jiang YY, Ding LW, He JZ, Xu XE, Hao JJ, Wang MR, Li CQ, Xu LY, Li EM^*, Berman BP^*, Koeffler HP. Identification of distinct mutational patterns and new driver genes in oesophageal squamous cell carcinomas and adenocarcinomas. Gut. 2018 Oct; 67 (10): 1769-1779.

10. Lin DC^#*, Hao JJ^#, Nagata Y^#, Xu L^#, Shang L, Meng X, Sato Y, Okuno Y, Varela AM, Ding LW, Garg M, Liu LZ, Yang H, Yin D, Shi ZZ, Jiang YY, Gu WY, Gong T, Zhang Y, Xu X, Kalid O, Shacham S, Ogawa S, Wang MR^*, Koeffler HP. Genomic and molecular characterization of esophageal squamous cell carcinoma. Nat Genet. 2014 May; 46 (5): 467-73.

Notes: ^# These authors contributed equally; ^* Correspondence.

主持或参与主要科研项目

中科院重点引进人才项目候选人，主持；

美国DeGregorio Family Foundation，主持；

先后参与国内外重大专项和国家自然基金等科研项目7项。

学术任职

担任Cell Death & Differentiation、Theranostics和FASEB J等多个SCI杂志审稿人。

联系方式

地址：安徽省合肥市蜀山湖路350号科学岛健康与医学技术研究所，邮编：230031

电话: +86-551-65596050

电子邮箱：yanyij@cmpt.ac.cn