中心简介:
主要开展肺部肿瘤(肺癌、肺结节等)相关疾病的多学科诊疗、科研和教学工作,设有肺部肿瘤外科、肺部肿瘤内科、肺部介入、肺部肿瘤放疗等4个专科主诊组,负责患者阶段性专科诊疗;配备4个肺癌专病管理组,负责对患者进行全程管理。
特色诊疗:
1.肺部肿瘤立体定向放射治疗
2.肺结节精准诊断
3.呼吸内镜综合介入诊疗
4.单孔胸腔镜下肺癌根治术
5.肺部肿瘤高低温复式消融技术(康博刀)
科研攻关:
1.主要承担的科研项目
(1)针对小细胞肺癌的高选择性ATR激酶抑制剂的发现研究,国家自然科学基金,2022
(2)含笑内酯调控HIF-1α/PD-L1对肺癌的放射增敏作用及机理研究,国家自然科学基金,2022
(3)靶向ATR 的选择性激酶抑制剂的结构优化及其在小细胞肺癌上的应用,安徽省自然科学基金,2021
(4)自噬在大气压非热等离子体致死肺癌A549细胞中的作用研究,安徽省自然科学基金,2020
(5)基于新型cfMeDIP-seq甲基化检测的肺结节良恶性无创分子诊断技术研发与临床应用,合肥市医疗卫生研发项目,2021
2.代表性论文:
(1)Haoran Yang, Peng Jiang, Dongyan Liu, Hong-Qiang Wang, Qingmei Deng, Xiaojie Niu, Li Lu, Haiming Dai, Hongzhi Wang, Wulin Yang. Matrix Metalloproteinase 11 is a potential therapeutic target in lung adenocarcinoma. Molecular Therapy-Oncolytics. 2019, 14: 82-93.
(2)Jie Ma, K.N. Yu, Cheng Cheng, Guohua Ni, Jie Shen, Wei Han. Targeting Nrf2-mediated heme oxygenase-1 enhances non-thermal plasma-induced cell death in non-small-cell lung cancer A549 cells. Archives of Biochemistry and Biophysics. 2018, 658: 54-65.
(3)Xinping Xie, Bin Gang, Wulin Yang, Hongqiang Wang. ctPath: Demixing pathway crosstalk effect from transcriptomics data for differential pathway identification. Journal of Biomedical Informatics. 2017, 73: 104-114.
(4)Jie Ma, Hao Zhang, Cheng Cheng, Jie Shen, Linzhi Bao, Wei Han. Contribution of hydrogen peroxide to non-thermal atmospheric pressure plasma induced A549 lung cancer cell damage. Plasma processes and Ploymers. 2016, 14(7): e1600162.
(5)Jue Hou, Jie Ma, K.N.Yu,Wei Li, Cheng Cheng, Lingzhi Bao, Wei Han. Non-thermal plasma treatment altered gene expression profiling in non-small-cell lung cancer A549 Cells. BMC Genomics. 2015, 16(1): 435.