中心简介:
主要开展肝胆胰等部位肿瘤(肝癌、胆癌、胰腺癌等)相关疾病的多学科诊疗、科研和教学工作,设有肝胆胰肿瘤外科、肝胆胰肿瘤内科、肝胆介入、肝胆胰肿瘤放疗等4个专科主诊组,负责患者阶段性专科诊疗;配备肝癌、胆胰肿瘤等4个专病管理组,负责对患者进行全程管理。
特色诊疗:
1.肝胆胰个体化微创外科治疗
2.肝脏、胰腺肿瘤的介入治疗技术
3.肝脏、胰腺肿瘤的精准放疗技术
4.数字智能化肝胆胰肿瘤诊疗核心技术
5.肝胆胰肿瘤的多学科综合诊疗
科研攻关:
1.主要承担的科研项目
(1)脂肪酸代谢信号轴LPL/FABP4/CPT1b活化对非酒精性脂肪性肝炎向肝癌演进的效应及其机制,国家自然科学基金,2019
(2)SVIL-HIF1α信号轴调控缺氧微环境诱导的肝癌转移机制研究,国家自然科学基金,2018
(3)一组新型肝细胞癌血清标志物的鉴定及其临床转化研究,安徽省卫健委科研项目,2021
(4)长链非编码RNA对肝癌细胞感应葡萄糖缺乏微环境的调控作用及机制研究,中科院合肥大科学中心项目,2020
2.代表性论文
(1)Haoran Yang, Qingmei Deng, Tun Ni, Yu Liu, Li Lu, Haiming Dai, Hongzhi Wang, Wulin Yang. Targeted Inhibition of LPL/FABP4/CPT1 fatty acid metabolic axis can effectively prevent the progression of nonalcoholic steatohepatitis to liver cancer. International Journal Of Biological Sciences. 2021, 17(15): 4207-4222.
(2)Xingxing Huo, Jian Qi, Kaiquan Huang, Su Bu, Wei Yao, Ying Chen, Jinfu Nie. Identification of an autophagy-related gene signature that can improve prognosis of hepatocellular carcinoma patients. BMC Cancer. 2020, 20(1): 771.
(3)Chenggang Zhao, Zhiyang Zhao, Zhen Wang, Lizhu Hu, Hongzhi Wang, Zhiyou Fang. Supervillin promotes tumor angiogenesis in liver cancer. Oncology Report. 2020, 44(2): 674-684.
(4)Xueran Chen, Shangrong Zhang, Zhen Wang, Fengsong Wang, Xinwang Cao, Quan Wu, Chenggang Zhao, Huihui Ma, Fang Ye, Hongzhi Wang, Zhiyou Fang. Supervillin promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma in hypoxia via activation of the RhoA/ROCK-ERK/p38 pathway. Journal of Experimental & Clinical Cancer Research. 2018, 37(1):128.
(5)Zongtao Hu, Feng Qin, Shile Gao, Yilan Zhen, Dake Huang, Liuyi Dong. Paeoniflorin exerts protective effect on radiation-induced hepatic fibrosis in rats via TGF-β1/Smads signaling pathway. American Journal of Translational Research. 2018, 10(3): 1012-1021.