中心简介：
主要开展食管、胃肠等部位肿瘤（食管癌、胃癌、肠癌等）相关疾病的多学科诊疗、科研和教学工作，设有食管肿瘤外科、胃肠肿瘤外科、食管胃肠肿瘤内科、消化介入、食管胃肠肿瘤放疗等5个专科主诊组，负责患者阶段性专科诊疗；配备食管癌、胃癌、肠癌等8个专病管理组，负责对患者进行全程管理。
特色诊疗：
1.直肠癌超低位保肛系列技术（新辅助放化疗序贯全腔镜微创根治性保肛手术，腔镜下经肛直肠癌根治术TaTME，经肛直肠复发癌近距离内照射技术）
2.胃癌根治系列技术（新辅助治疗序贯胃癌根治术，3D腹腔镜胃癌根治术、双通道保功能胃癌根治吻合技术）
3.腹膜转移癌肿瘤细胞减灭+腹腔热灌注化疗术（联合原代细胞培养肿瘤药物敏感性筛查技术）
科研攻关：
1.主要承担的科研项目
（1）超级增强子相关癌基因ELF3促进食管癌细胞增殖的分子机制研究，国家自然科学基金，2023
（2）TP63抑制食管癌中CD8+T细胞浸润/活化的分子机制研究，国家自然科学基金，2022
（3）食管鳞癌特异性TP63超级增强子元件的功能及形成机制研究，国家自然科学基金，2022
（4）食管鳞癌驱动性TP63超级增强子元件的鉴定与功能研究，安徽省自然科学基金，2022
（5）克服cKIT激酶耐药突变的新型胃肠间质瘤候选靶向药物TR-64的临床前研究，安徽省重大专项，2021
2.代表性论文
（1）Juan Liu, Jingjing Gao, Aoli Wang, Zongru Jiang, Shuang Qi, Ziping Qi, Feiyang Liu, Kailin Yu, Jiangyan Cao, Cheng Chen, Chen Hu, Hong Wu, Li Wang, Wenchao Wang, Qingsong Liu, Jing Liu. Nintedanib overcomes drug resistance from upregulation of FGFR signalling and imatinib-induced KIT mutations in gastrointestinal stromal tumours. Molecular Oncology. 2022, 16(8): 1761-1774.
（2）Yanyi Jiang, Yuan Jiang, Chunquan Li, Ying Zhang, Pushkar Dakle, Harvinder Kaur, Jian-Wen Deng, Ruby Yu-Tong Lin, Lin Han, Jianjun Xie, Yiwu Yan, Ngan Doan, Yueyuan Zheng, Anand Mayakonda, Masaharu Hazawa, Liang Xu, YanYu Li, Luay Aswad, Maya Jeitany, Deepika Kanojia, Xin-Yuan Guan, Jonathan W Said, Wei Yang, Melissa J Fullwood, De-Chen Lin, H Phillip Koeffler. TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines. Gastroenterology. 2020, 159(4): 1311-1327.
（3）Yun Wu, Beilei Wang, Junjie Wang, Shuang Qi, Fengming Zou, Ziping Qi, Feiyang Liu, Qingwang Liu, Cheng Chen, Chen Hu, Zhenquan Hu, Aoli Wang, Li Wang, Wenchao Wang, Tao Ren, Yujiao Cai, Mingfeng Bai, Qingsong Liu, Jing Liu. Discovery of 2-(4-chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)acetamide (CHMFL-KIT-64) as a Novel Orally Available Potent Inhibitor against Broad Spectrum Mutants of c-KIT Kinase for Gastrointestinal Stromal Tumors. Journal of Medicinal Chemistry. 2019, 62(13): 6083-6101.
（4）Xuesong Liu, Beilei Wang, Cheng Chen, Ziping Qi, Fengming Zou, Junjie Wang, Chen Hu, Aoli Wang, Juan Ge, Qingwang Liu, Kailin Yu, Zhenquan Hu, Zongru Jiang, Wei Wang, Li Wang, Wenchao Wang, Tao Ren, Mingfeng Bai, Qingsong Liu, Jing Liu. Discovery of (E)-N-1-(3-Fluorophenyl)-N-3-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)malonamide (CHMFL-KIT-033) as a Novel c-KIT T670I Mutant Selective Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs). Journal of Medicinal Chemistry. 2019, 62(10): 5006-5024.
（5）Yuan Jiang, Yanyi Jiang, Jianjun Xie, Anand Mayakonda, Masaharu Hazawa, Li Chen, Jinfen Xiao, Chunquan Li, Moli Huang, Lingwen Ding, Qiaoyang Sun, Liang Xu, Deepika Kanojia, Maya Jeitany, Jianwen Deng, Liandi Liao, Harmik J Soukiasian, Benjamin P Berman, Jiajie Hao, Liyan Xu, Enmin Li, Mingrong Wang, Xingang Bi, Dechen Lin, H Phillip Koeffler. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression. Nature Communication. 2018, 9(1): 3619.
