简历：

洪波，中国科学院合肥物质院健康所精准医学诊断技术研究中心研究员，硕士生导师，中国科学院合肥肿瘤医院肿瘤转化医学研究中心中心实验室主任。2003年毕业于安徽大学获得学士学位。2006年毕业于中国科学技术大学获得硕士学位。2009年毕业于香港中文大学获得博士学位。2010-2015年先后在宾夕法尼亚州立大学医学院和美国国立卫生研究院国家人类基因组研究所从事博士后研究。

研究方向：

应用高通量基因测序、多组学生物信息分析和高通量药物筛选技术，针对临床问题开展以下研究：

1）肺结节良恶性诊断

2）罕见肿瘤的精准诊断

3）肿瘤的治疗抵抗

招生专业：

学术硕士招生计划：

1、专业：生物物理学（硕士）招生方向：肿瘤生物学

2、专业：生物物理学（硕士）招生方向：肿瘤药物学

专业学位硕士招生计划：

1、专业：生物与医药（专硕）招生方向：肿瘤生物学

2、专业：生物与医药（专硕）招生方向：肿瘤药物学

发表论文：

1. Hong B, Prabhu VV, Zhang S, van den Heuvel AP, Dicker DT, Kopelovich L, El-Deiry WS*. Prodigiosin rescue deficient p53 signaling and anti-tumor effects via p73 upregulation and disruption of mutant p53:p73 interaction. Cancer Research. 2014. 74(4):1153-1165.

2. Zhang X, Qi J, Wang J, Wang Z, Wang Y, Hu Z, Xu A*, Hong B*, Wang H*. Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed-Type Thyroid Cancer. Advanced Science. 2026. 13(1):e07602. （*共同通讯）

3. Fu M, Zhu Q, Qi J, Zhang X, Wang Z, Wang J, Huang X, Hu Z, Wang W*, Hong B*, Wang H*. Integrated methylome analysis identifies an epigenetically silenced tumor suppressor RASA4 in small cell lung cancer. Communications Biology. 2025. 9(1):161. （*共同通讯）

4. Xu A^#, Wang W^#, Nie J, Lui VWY, Hong B*, Lin W*. Germline mutation and aberrant transcripts of WWOX in a syndrome with multiple primary tumors. Journal of Pathology. 2019. 249(1):19-25.（*共同通讯）

5. Yin YP^#, Shi WH^#, Deng K, Liu XL, Li H, Lv XT, Lui VWY, Ding C*, Hong B*, Lin WC*. Combinations of proteasome inhibitors with obatoclax are effective for small cell lung cancer. Acta Pharmacologica Sinica. 2021. 42(8):1298-1310.（*共同通讯）

6. Zhu Q, Fu M, Qi J, Xu Z, Wang Y, Wang Z, Wang D, Liu J, Du R, Wei X, Wang H, Nie J, Hong B*, Xu W*. Cisplatin resistance-related transcriptome and methylome integration identifies PCDHB4 as a novel prognostic biomarker in small cell lung cancer. iScience. 2024. 27(8):110413.

7. Qi J^#, Hong B^#*, Tao R, Sun R, Zhang H, Zhang X, Ji J, Wang S, Liu Y, Deng Q, Wang H*, Zhao D*, Nie J*. Prediction model for malignant pulmonary nodules based on cfMeDIP-seq and machine learning. Cancer Science. 2021. 112(9):3918-3923. (#共同第一、*共同通讯)

8. Cheng Y, Xu Y, Zhang X, Qi J, Wang J, Liu Y, Wan K, Liu Y, Yu L, Wang H, Nie J, Hong B*, Wang Y*. Characterization of somatic mutations of colorectal tumor in a patient with concurrent APC and MLH1 germline mutations. Genes & Diseases. 2023. 10(6):2245-2247. (*共同通讯)

9. Hong B, Le Gallo M, Bell DW*. The mutational landscape of endometrial cancer. Current Opinion in Genetics & Development. 2015. 30C:25-31.

10. Gao R^#, Bian Y^#, Wang Y^#, Zhang Y, Zhu Q, Nie J, Hu Z, Wang H*, Hong B*. NEDD4 is a biomarker of a poor prognosis that contributes to the progression and chemoresistance in small cell lung cancer. Cell Cycle. 2025. 24(9-12):204-219. (*共同通讯)

11. Wang Y^#, Du R^#, Gao R^#, Guo C, Qi J, Zhang Y, Zhu Q, Deng Q, Hu Z, Wang H*, Hong B*. Disulfiram potentiates cisplatin-induced apoptosis in small cell lung cancer via the inhibition of cystathionine β-synthase and H2S. American Journal of Cancer Research. 2025. 15(4):1647-1661. (*共同通讯)

12. Fu M, Feng C, Wang J, Guo C, Wang Y, Gao R, Wang J, Zhu Q, Zhang X, Qi J, Zhang Y, Bian Y, Wang Z, Fang Y, Cao L*, Hong B*, Wang H*. CD3, CD8, IFN-gamma, tumor and stroma inflammatory cells as prognostic indicators for surgically resected SCLC: evidences from a 10-year retrospective study and immunohistochemical analysis. Clinical And Experimental Medicine. 2024. 24(1):99. (*共同通讯)

13. Wang J^#, Wang J^#, Huang X, Zhou Y, Qi J, Sun X, Nie J, Hu Z, Wang S, Hong B*, Wang H*. CT radiomics-based model for predicting TMB and immunotherapy response in non-small cell lung cancer. BMC Medical Imaging. 2024. 24(1):45.（*共同通讯）

14. Zhang Y, Zhu Q, Qi J, Fu M, Xu A, Wang W, Wang H, Nie J, Hong B*. The identification of a two-gene prognostic model based on cisplatin resistance-related ceRNA network in small cell lung cancer. BMC Medical Genomics. 2023. 16(1):103.

15. Du R^#, Sun F^#, Li K^#, Qi J, Zhong W, Wang W, Sun Q, Deng Q, Wang H, Nie J, Ding C*, Hong B*. Proteomics analysis revealed SMAD3 as a potential target of the synergistic anti-tumor activity of disulfiram and cisplatin in ovarian cancer. Anti-Cancer Agents in Medicinal Chemistry. 2023. 23(15):1754-1764. (*共同通讯)

16. Bian X*, Sun C, Cheng J, Hong B*. Targeting DNA Damage Repair and Immune Checkpoint Proteins for Optimizing the Treatment of Endometrial Cancer. Pharmaceutics. 2023. 15(9):2241.（*共同通讯）

17. Sun F, Wang H, Nie J, Hong B*. Repurposed disulfiram as the chemo-therapeutic sensitizer: molecular targets and mechanisms，Anti-Cancer Agents in Medicinal Chemistry. 2022. 22(17):2920-2926.  

18. Ji S^#, Chen Y^#, Zhao X^#, Cai Y*, Zhang X, Sun F, Chen Q, Deng Q, Wang C, Ma K, Hong B*, Liang C*. Surface morphology and payload synergistically caused an enhancement of the longitudinal relaxivity of a Mn3O4/PtOx nanocomposite for magnetic resonance tumor imaging. Biomaterials Science. 2021. 9(7):2732-2742. (*共同通讯)

19. Tao R^#, Cao W^#, Zhu F^#, Nie J, Wang H, Wang L, Liu P, Chen H, Hong B*, Zhao D*. Liquid biopsies to distinguish malignant from benign pulmonary nodules. Thoracic Cancer. 2021. 12(11):1647-1655. (*共同通讯）

20. Fang J^#, Wang W^#, Fang J, Wang H, Lin L, Li F, Sun Q, Li F, Qi J, Sun X, Huo X, Wang S, Wang H, Hong B*, Deng Q*, Nie J*. Epithelial-mesenchymal transition classification of circulating tumor cells in lung and colon cancer patients: potential role in clinical practice, Translational Cancer Research, 2020. 9(11)：6639-6651. (*共同通讯）

21. Deng K, Shen J, Wang W, Li M, Li H, Chen C, Zhao H, Zhang M, Xue T, Liu Q, Lui VW, Hong B*, Lin W*. Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer. Cancer Biology & Therapy. 2019. 20(1):52-64. (*共同通讯)

22. Liu X, Wang W, Yin Y, Li M, Li H, Xiang H, Xu A, Mei X, Hong B*, Lin W*. A high-throughput drug screen identifies auranofin as a potential sensitizer of cisplatin in small cell lung cancer. Investigational New Drugs. 2019. 37(6):1166-1176. (*共同通讯)

23. Huang X, Jiao L, Cheng X, Fang Y, Qi J, Hu Z, Hong B*, Nie J, Wang H*. A TP53-Pathway-Based Prognostic Signature for Radiotherapy and Functional Validation of TP53I3 in Non-Small-Cell Lung Cancer. Cancers. 2026. 18(3):457.（*共同通讯）

24. Ye F, Yin Y, Wang J, Wang J, Yang J, Zhang J, Zhang Y, Qi J, Zhu Q, Zhang Y, Ji H, Hu Z, Hong B*, Wang H*. A lncRNA and radiomics-based model for predicting the response of non-small cell lung cancer to chemo- and radio-therapy. Scientific Reports. 2026. 16(1):8337.（*共同通讯）

25. Wang J^#, Guo C^#, Wang J^#, Zhang X, Qi J, Huang X, Hu Z, Wang H*, Hong B*. Tumor Mutation Signature Reveals the Risk Factors of Lung Adenocarcinoma with EGFR or KRAS Mutation. Cancer Control. 2025. 32:10732748241307363. (*共同通讯)

26. Li H, Wang H, Deng K, Han W, Hong B*, Lin W*. The ratio of Bcl-2/Bim as a predictor of cisplatin response provides a rational combination of ABT-263 with cisplatin or radiation in small cell lung cancer. Cancer Biomarkers. 2019;24(1):51-59. (*共同通讯)

27. Hong B, Wang H, Deng K, Wang W, Dai H, Lui VW, Lin W*. Combination treatment of RAD001 and BEZ235 exhibits synergistic antitumor activity via down-regulation of p-4E-BP1/Mcl-1 in small cell lung cancer. Oncotarget. 2017.8(63): 106486-106498.

28. Wang H^#, Hong B^#, Li X, Deng K, Li H, Lui VW, Lin W*. JQ1 synergizes with the Bcl-2 inhibitor ABT-263 against MYCN-amplified small cell lung cancer, Oncotarget. 2017. 8(49): 86312-86324. (#共同第一)

29. Hong B, van den Heuvel AP, Prabhu VV, Zhang S, El-Deiry WS*. Targeting tumor suppressor p53 for cancer therapy: strategies, challenges and opportunities. Current Drug Targets. 2014. 15(1):80-89.

30. Hong B, Lui VW, Hashiguchi M, Hui EP, Chan AT*. Targeting tumor hypoxia in nasopharyngeal carcinoma. Head & Neck. 2013. 35(1):133-145.

31. Hong B^#, Lui VW^#, Hui EP, Ng MH, Cheng SH, Sung FL, Tsang CM, Tsao SW, Chan AT*. Hypoxia-targeting by Tirapazamine (TPZ) Induces Preferential Growth Inhibition of Nasopharyngeal Carcinoma Cells with Chk1/2 Activation. Investigational new drugs. 2011. 29(3):401-410. (#共同第一)

32. Hong B^#, Lui VW^#, Hui EP, Lu Y, Leung HS, Wong EY, Cheng SH, Ng MH, Mills GB, Chan AT*. Reverse Phase Protein Array Identifies Novel Anti-invasion Mechanisms of YC-1. Biochemical Pharmacology. 2010. 79(6):842-852. （#共同第一）

33. Hong B, Zhang ZF, Tang SM, Yi YZ, Zhang TY, Xu WH*. Protein-DNA interactions in the promoter region of the gene encoding diapause hormone and pheromone biosynthesis activating neuropeptide of the cotton bollworm, Helicoverpa armigera. Biochim Biophys Acta. 2006. 1759(3-4):177-185. 

科研项目：

目前承担和参与的研究课题包括国家科技重大专项，国家自然科学基金面上项目，国家自然科学基金青年科学基金项目，安徽省自然科学基金面上项目，合肥市留学回国人员创新创业扶持计划，合肥大科学中心协同创新培育基金等。

联系方式：

Email: bhong@hmfl.ac.cn 

地址：安徽省合肥市蜀山区仰桥路68号中国科学院合肥肿瘤医院科研楼407